ABSTRACT
Cognition is a process of knowing. When it is impaired, reviving is needed. Studies to bustle off the psychomotor activities using non steroidal anti-inflammatory drugs revealed variable results. The aim of this study is to evaluate the effects of single oral dose of celecoxib and meloxicam on cognitive activity in healthy, young volunteers. Fourteen healthy young volunteers were participated, allocated into two groups. After a7-day washed-out period, each volunteer was randomly given a single oral dose of either celecoxib or meloxicam or placebo. Psychomotor tests were performed to record participants' sensory and motor reactions. placebo-administered subjects had non-significant changes in both choice reaction time and critical flicker fusion. Celecoxib-administered participants had a significantly reduced recognition reaction time without a significant effect on motor reaction time. While meloxicam-administered participants had a significant reduction in motor reaction time without a significant effect on recognition reaction time. All drug-given participants had a non-significant change in choice reaction time when compared with corresponding baseline and placebo values. Cox-2 inhibitors have no place in improving the cognition
Subject(s)
Humans , Male , Female , Adult , Cyclooxygenase 2 Inhibitors , Placebos , Flicker Fusion/drug effectsABSTRACT
The effects of diazepam, propranolol or alcohol alone or in combination with each other were examined in ten normal healthy volunteers on tests of psychomotor function. Results showed impaired psychomotor performance persisting upto 4-5 h when the aforementioned agents given singly were tested on simple reaction time (SRT), multiple choice reaction time (MCRT) and critical flicker fusion frequency (CFFF) tasks. Digit cancellation task (DCT) was similarly affected by diazepam and alcohol only. No summation of adverse effects on psychomotor performance was noted when a combination of diazepam and alcohol, diazepam-propranol or alcohol plus propranolol were tested on SRT and MCRT. An additive impairment of CFFF was observed with alcohol - propranolol combination only. No summation of pharmacodynamic effects on DCT were noted when different combinations were used.
Subject(s)
Adult , Anti-Anxiety Agents/pharmacokinetics , Central Nervous System Depressants/pharmacokinetics , Cognition/drug effects , Diazepam/pharmacokinetics , Drug Interactions , Ethanol/pharmacokinetics , Flicker Fusion/drug effects , Humans , Hypnotics and Sedatives/pharmacokinetics , Male , Propranolol/pharmacokinetics , Psychomotor Performance/drug effects , Reaction Time/drug effectsABSTRACT
The effects of fencamfamine (25 and 50 mg po) were studied on acute psychophysiological and psychomotor performance in six healthy male volunteers. Stimulant effects, such as greater increases of critical flicker-fusion thereshold, heart rate, blood pressure and stimulation assessed by self-rating, were more pronounced with the higher dose of fencamfamine. Paradoxical sedative effects were obrained with the 25 mg dose. Fencamfamine should not be considered only as an energizing agent, but also as an agent having a psychostimulant profile of effects